摘要
Emerging variants of known RNA viruses present an increasing threat to mankind worldwide through their enlarging impact on morbidity and mortality. One of them is the chikungunya disease, which becomes a major public health problem and economic threat. Current world has no approved antiviral drugs available against chikungunya infection. This Book Chapter mainly focuses on discussion of the antiviral compounds that have been reported to inhibit chikungunya virus replication. Various syntheses of antiviral agents, compounds isolated from natural sources, and some structure-activity relationships are illustrated.