摘要
Extended-nano space, which is in 10-1000 nm scale, is a transitional region from single molecules to continuous fluid. Even though many specific effects are expected, device engineering of extended-nano space has not been developed so far due to the lack of basic technologies for fluidic engineering. Previously, our group established a strategy of device integration for microchemical systems called continuous flow chemical processing and applied the strategy to various analytical systems. In addition, we have succeeded in developments of basic technologies including fabrication, fluidic control and detection for extended-nano space to find very unique effects such as higher viscosity, lower dielectric constant and higher proton mobility. In this chapter, the uniqueness, device engineering of extended-nano space and its application to bioanalytical devices are introduced. Especially, we focus on an ultimate chromatography using extended-nano space and its innovative performances to break the limits of conventional technologies.