Logo image
Human genetics and assisted reproduction in endometriosis
Book chapter

Human genetics and assisted reproduction in endometriosis

Ya-Ching Chou, Chien-Wen Chen, Endah Rahmawati, Guan-Lin Lai, Yun-Yi Ma, Yi-Xuan Lee, Ming-Jer Chen and Chii-Ruey Tzeng
Human Reproductive and Prenatal Genetics, pp.633-655
01/2023

Abstract

Adenomyosis Assisted reproduction Biomarkers Blood heavy metals Endocrine-disrupting chemicals Endometriosis Phthalate Biochemistry Genetics and Molecular Biology (all)
Endometriosis is a prevalent disease imposing detrimental impacts on women health and fecundity. Although detection of asymptomatic endometriosis is challenging at present, studies reveal promising results of detecting asymptomatic endometriosis with a panel of biomarkers. Endometriosis is associated with blood trace metals. While blood zinc displays a protective role against endometriosis, the relationship between blood lead and endometriosis remains unclear. Phthalates disturb human endocrines and are associated with endometriosis and poor development of oocytes and embryos. For women with endometriosis suffering infertility, assisted reproduction is the most efficient treatment. While the most appropriate treatment remains controversial in recurrent endometriosis, cystectomy of the endometrioma should always be replaced by cyst aspiration in order to preserve the ovarian reserve. Although the association between adenomyosis and infertility has not been well established, assisted reproduction following pituitary downregulation or surgical removal of the endometriotic lesions is both efficient managements for infertile women with adenomyosis.

Metrics

1 Record Views

Details

Logo image