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A multifunctional embryos manipulative microfluidic chip with dynamic flow resistance trapping and CO-culture with stromal cells
Conference paper

A multifunctional embryos manipulative microfluidic chip with dynamic flow resistance trapping and CO-culture with stromal cells

Tzu-Wei Lo, Yu-Shih Chen, Ling-Yi Ke, Ming-Xiang Dong, Yao-Shien Huang, Hong-Yuan Huang and Cheng-Hsien Liu
TRANSDUCERS 2017 - 19th International Conference on Solid-State Sensors, Actuators and Microsystems, pp.548-551
07/2017

Abstract

co-culture embryo manipulation embryo trapping stromal cells Uterus-mimicking Chemical Health and Safety Instrumentation Electrical and Electronic Engineering
In order to optimize the quality of embryos culture, more factors are used to improve the quality of embryos. This microfluidic device integrates the various functions, such as the trapping mechanism of dynamic flow resistance, and co-culture embryos with human stromal cells providing the growth factors. For the main function, embryos can be manipulated by fluidic field in the G-type co-culture chamber (GCC), which can make the embryos grow better by keeping them moving when co-culturing. It's expected that the successful rate of embryos development and the quality can be improved by constructing the suitable environment to provide the physical stimulus for the embryos.

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