Absolute Cerebral Volume Quantification by Vascular Space Occupancy Technique on Rat Model with Optimized Inversion Time

Recently a new approach to measure the absolute cerebral blood volume (aCBV) has been reported by utilizing the signal difference of vascular space occupancy (VASO) sequence before and after injection of T1 shortening contrast agent.[1] In spite of possible variation of the T1 of blood may exists, a fixed inversion time (TI) was used in the previous report. In this study, the information of relative cerebral blood volume (rCBV) from dynamic susceptibility contrast (DSC) imaging is included to optimize the TI for the aCBV quantification by VASO method on a rat  model.