Abstract
An integrated microfluidic system was developed to automatically perform systematic evolution of ligands and exponential enrichment (SELEX) process using combinational single-stranded DNA (ssDNA) library for rapid screening of highly specific aptamers for influenza viruses in this study. This integrated microfluidic system consisted of several modules on a single chip. With this system, the specific aptamers were screened successfully with high affinity for influenza viruses after several repeated extraction and amplification runs. Therefore, it may provide a useful platform for specific aptamers screening, which can be a promising biomarker to recognize viruses for fast diagnosis.