Abstract
Thermal lens microscope (TLM) is a kind of absorption spectrometry with a sensitivity of single molecules in fL detection volume. In this paper, we report a newly functionalized TLM for selective and sensitive detection of chiral samples. We developed a circular dichroism (CD) thermal lens microscope by light phase modulation. We verified the basic principle and achieved two orders higher sensitivity than CD spectrometer. Copyright © 2005 by the Transducer Research Foundation, Inc.