Abstract
Paper-based microfluidic chips provide a novel way to carry out microfluidic analysis. Such chips achieve lab-on-paper instead of traditional lab-on-chips. The paper substrate is attractive because it is cost-effective, easy to use and disposable. The routing problem of paper-based digital microfluidic (PB-DMF) biochips is to realize bio-chemical operations on paper with inkjet printing techniques. We propose a routing scheme targeting multiple preprogrammed droplet paths such that both routability and wire-length are optimized in a paper layer. Compared with previous digital microfluidic (DMF), the proposed paper-based DMF needs only one integrated paper layer instead of two layers of control and signal layers in the traditional DMF. Experimental results on a set of paper chip applications show the effectiveness, efficiency and scalability of the proposed algorithm.