Abstract
Here we report a cell-based separation microdevice using human renal proximal tubule epithelial cells. Near organ-level of separation efficiency and selectivity including reabsorption and clearance by renal tubule cells was demonstrated on chip. In addition, cell performance was directly measured under different operating parameters (flow rate and feeding concentration) in order to optimize the cell separating capability. This cell-base separation microdevice also referred to as bioartificial renal tubule on chip has the potential for drug screening and portable medical care device for kidney failure [1].