DNA Damage analysis in microfluidic chips

Yuki Tanaka; Henrik Johansson; Chatarina Larsson; Jonas Jarvius; Takehiko Kitamori; Mats Nilsson

Conference paper

DNA Damage analysis in microfluidic chips

Yuki Tanaka, Henrik Johansson, Chatarina Larsson, Jonas Jarvius, Takehiko Kitamori and Mats Nilsson

Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007, pp.994-996

2007

Appears in keyword about Chemistry

Abstract

In situ

Single cell

Single molecule

Chemical Engineering (miscellaneous)

Bioengineering

This paper reports mitochondrial DNA damage analysis in single cells using a microfluidic platform. DNA damage and single-nucleotide polymorphisms (SNPs) in individual mitochondrial DNA molecules were analyzed using padlock probes, made visible by rolling-circle amplification of the circularized padlock probes. By combining microfluidcs with padlock probes, individual cells have been manipulated and investigated with single-molecule sensitivity.

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Title: DNA Damage analysis in microfluidic chips
Translated title: DNA Damage analysis in microfluidic chips
Creators - without role: Yuki Tanaka - Uppsala University
Henrik Johansson - Uppsala University
Chatarina Larsson - Uppsala University
Jonas Jarvius - Uppsala University
Takehiko Kitamori - The University of Tokyo
Mats Nilsson - Uppsala University
Publication Details: Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007, pp.994-996
Identifiers: 9780979806407; 9957771296006774
Academic Unit: Institute of NanoEngineering and Microsystems, College of Engineering, National Tsing Hua University
Language: English
Resource Type: Conference paper

DNA Damage analysis in microfluidic chips

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