Development of Laplace valve on hydrophilic surfaces using micro-nano structure and pinning effect

We developed a Laplace valve working even on hydrophilic surfaces to prevent adsorption of biological molecules onto surfaces using pinning effect which enhances the contact angle by micro-nano structures. A fluidic operation for pretreatment in single cell analysis was successfully performed using this Laplace valve. This method will be an important tool for fluid controls in micro-nanofluidics.