Development of UV thermal lens microscope (UV-TLM) for ultrasensitive and direct detection of non-labeled biomolecules on a microchip

Manabu Tokeshi; Shinichiro Hiki; Kazuma Mawatari; Akihide Hibara; Takehiko Kitamori

Conference paper

Development of UV thermal lens microscope (UV-TLM) for ultrasensitive and direct detection of non-labeled biomolecules on a microchip

Manabu Tokeshi, Shinichiro Hiki, Kazuma Mawatari, Akihide Hibara and Takehiko Kitamori

Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Vol.1, pp.452-454

2005

Appears in keyword about Chemistry

Abstract

Non-labeled biomolecules

Quasi-continuous wave

Thermal lens microscope

Ultraviolet pulse laser

Chemical Engineering (miscellaneous)

Bioengineering

This paper describes the development of an ultraviolet thermal lens microscope (UVTLM) that can detect directly non-labeled biomolecules in microchips. The performance of the UV-TLM was evaluated by the limit of detection (LOD) using standard solution of adenine. The LOD for adenine was calculated to be 1.4×10 M. This sensitivity was 100 times higher than that obtained by conventional spectrophotometry. Copyright © 2005 by the Transducer Research Foundation, Inc.

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Title: Development of UV thermal lens microscope (UV-TLM) for ultrasensitive and direct detection of non-labeled biomolecules on a microchip
Translated title: Development of UV thermal lens microscope (UV-TLM) for ultrasensitive and direct detection of non-labeled biomolecules on a microchip
Creators - without role: Manabu Tokeshi - Kanagawa Academy of Science and Technology
Shinichiro Hiki - Institute of Microchemical Technology
Kazuma Mawatari - Kanagawa Academy of Science and Technology
Akihide Hibara - The University of Tokyo
Takehiko Kitamori - Kanagawa Academy of Science and Technology
Publication Details: Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Vol.1, pp.452-454
Identifiers: 0974361119; 9780974361116; 9957768468006774
Academic Unit: Institute of NanoEngineering and Microsystems, College of Engineering, National Tsing Hua University
Language: English
Resource Type: Conference paper

Development of UV thermal lens microscope (UV-TLM) for ultrasensitive and direct detection of non-labeled biomolecules on a microchip

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