Development of differential interference contrast thermal lens microscope for counting individual nonfluorescent molecules

Hisashi Shimizu; Kazuma Mawatari; Takehiko Kitamori

Conference paper

Development of differential interference contrast thermal lens microscope for counting individual nonfluorescent molecules

Hisashi Shimizu, Kazuma Mawatari and Takehiko Kitamori

12th International Conference on Miniaturized Systems for Chemistry and Life Sciences - The Proceedings of MicroTAS 2008 Conference, pp.1591-1593

2008

Abstract

Differential interference contrast

Photothermal spectroscopy

Single molecule detection

Chemical Engineering (miscellaneous)

Bioengineering

We present a novel single molecule detection technique using a Differential Interference Contrast Thermal Lens Microscope (DIC-TLM). DIC-TLM detects a phase difference generated by a thermal relaxation and its background-free optical system realizes sensitive detections of non-fluorescent substances. In this paper, we report the single molecule detection of porphyrin by the DIC-TLM.

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Title: Development of differential interference contrast thermal lens microscope for counting individual nonfluorescent molecules
Translated title: Development of differential interference contrast thermal lens microscope for counting individual nonfluorescent molecules
Creators - without role: Hisashi Shimizu - Department of Applied Chemistry, University of Tokyo
Kazuma Mawatari - Kanagawa Academy of Science and Technology
Takehiko Kitamori - Department of Applied Chemistry, University of Tokyo
Publication Details: 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences - The Proceedings of MicroTAS 2008 Conference, pp.1591-1593
Identifiers: 9957772001406774
Academic Unit: Institute of NanoEngineering and Microsystems, College of Engineering, National Tsing Hua University
Language: English
Resource Type: Conference paper

Development of differential interference contrast thermal lens microscope for counting individual nonfluorescent molecules

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