Development of differential interference contrast thermal lens microscope

H. Shimizu; K. Mawatari; T. Kitamori

Conference paper

Development of differential interference contrast thermal lens microscope

H. Shimizu, K. Mawatari and T. Kitamori

Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007, pp.458-460

2007

Appears in keyword about Chemistry

Abstract

Differential interference contrast

Gold nanoparticle

Photothermal

Chemical Engineering (miscellaneous)

Bioengineering

We present a new background-free photothermal spectroscopy based on thermal lens microscope (TLM) to realize single molecule counting. For single molecule counting, approximately 20 times increase of sensitivity is necessary compared with conventional TLMs. For this purpose, a new differential interference contrast thermal lens microscope (DIC-TLM) was developed. The basic principle was verified, and sensitivity was proved to be 5 times higher than conventional TLMs. We believe single molecule counting will be possible with some improvements.

Metrics

1 Record Views

Details

Title: Development of differential interference contrast thermal lens microscope
Translated title: Development of differential interference contrast thermal lens microscope
Creators - without role: H. Shimizu - School of Engineering , University of Tokyo
K. Mawatari - Kanagawa Academy of Science and Technology
T. Kitamori - School of Engineering , University of Tokyo
Identifiers: 9780979806407; 9957773033406774
Academic Unit: Institute of NanoEngineering and Microsystems, College of Engineering, National Tsing Hua University
Language: English
Resource Type: Conference paper
Publication Details: Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007, pp.458-460

Development of differential interference contrast thermal lens microscope

Abstract

Related links

Metrics

Details

National Tsing Hua University Social media