Abstract
Here we report a development of fL (10 L) mess-pipette (volumetric pipette) utilizing precise fabrication of 100-nm structure on fused silica and hydrophobic Laplace valve. During verification of fL volumetric pipette, we discovered that drying of sample is the key issue on fL liquid handling in gas phase. By quick application of pressure (~ms), we minimized the effect of drying and 11 fL of water was successfully isolated and transported without loss. This study will greatly contribute to analytical chemistry by providing a novel method of volumetry and manipulation of fL liquid.