Abstract
Understanding fluid and interfacial properties in inter/intracellular space is crucial for biological system. Here, an in vitro method to simultaneously measure the viscosity and wetting property was developed using capillary filling controlled by MPa external pressure in bio-mimetic extended-nano space (10 -10 nm) which mimicked inter/intracellular space (10 -10 nm). Bio-mimetic extended-nanoconfinement effect on water properties was evaluated. It suggested that specificity of two-dimensionally nanoconfined channel, in which the viscosity showing much higher values than bulk, while wetting property is independent on bio-mimetic extended-nanoconfinement. This study will offer a deeper understanding of biological fluid and also contribute to biological system design.