Development of micro/extended-nano filtering interface with extended-nanopillars

We developed micro/extended-nano filtering interface using extended-nanopillars which is essential for sample introduction into extended-nano spaces (10-1000 nm) from micro spaces without clogging. To connect micro spaces (pL volume: 10 L) and extended-nano spaces (fL volume: 10 L), interface which had extended-nanopillars for filtering was successfully integrated in a chip. By introduction of beads and lysed cell samples, principle of filtering was verified.