Abstract
We here report a development of polymer-modification method utilizing surface-initiated atom transfer radical polymerization (SI-ATRP) for creation of functional space in a few hundreds nanometer-sized channel (so-called extended nanos-pace). The method which integrates bottom-up polymer-modification method with top-down fabrication technology allows us to create an extremely small-sized multi-functional space. Availability confirmation of this SI-ATRP method was first performed on microspace, and then we suggested unique function of polymer-modified extended nanospace for novel protein separation device.