Abstract
Many people worldwide are suffering from joint diseases such as rheumatoid arthritis or osteoarthritis, but due to devoid of vasculature, lymphatics, and nervous system, articular cartilage (AC) as connective tissue in adult joint has limited capability to repair and rehabilitate [3]. Tissue engineering (TE) with the purpose of replacement, repairment and regeneration of dysfunctional tissue has become a promising tool to deal with joint defect in orthopedics. To develop scaffolds with simulations of the unique and complex structure is of great importance in TE. This paper provided a tissue-specific design of hydrogel scaffolds with simulated biophysical features for engineering AC by using digital light processing (DLP)-based 3D printing.