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Guiding 3d podocyte cells cultivation on the outer coaxial alginate tubes to make glomerular on the chip
Conference paper

Guiding 3d podocyte cells cultivation on the outer coaxial alginate tubes to make glomerular on the chip

Yin-Yun Chen, Jyun-Wei Chen, Jie-Sheng Chen, Yi-Ching Ko, Hsiang-Hao Hsu and Fan-Gang Tseng
23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019, pp.1596-1597
2019

Abstract

Alginate Co-shelled tube Podocyte Tissue Engineering Bioengineering Chemical Engineering (miscellaneous)
In this research, we demonstrate successful glomerular cells cultivation outside co-shelled alginate tubes rather than cells cultivation inside the alginate tubes to reduce the interference of growth space on cell proliferation and differentiation. Podocytes were seeded on the outerior of an alginate tube by a tube infiltration method into a cell culturing site, and cells were successfully attached on the outer of the alginate tube and formed tubular structures instead of a cellular microfiber tube after 7 days cultivation. The reconstructed glomerular tube will be used as an in-vitro model for drug testing, and also the first step toward re-establishing a fully functional artificial glomerular.

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