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In Vitro Development of the Embryo in a Microfluidic Device for Automatic Embryo Trapping and Co-Culture with Endometrial Cells
Conference paper

In Vitro Development of the Embryo in a Microfluidic Device for Automatic Embryo Trapping and Co-Culture with Endometrial Cells

Shalaka Bhosale, Mushou Chen and Cheng-Hsien Liu
2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII, pp.736-739
06/2019
DOI: https://doi.org/10.1109/TRANSDUCERS.2019.8808655
Appears in  keyword about Chemistry

Abstract

3T3 cells Cell Trapping Coculture hydrodynamic trapping In Vitro Culture Reproductive Technology Process Chemistry and Technology Spectroscopy Electrical and Electronic Engineering Mechanical Engineering Electronic Optical and Magnetic Materials Control and Optimization Instrumentation
The quality of in vitro developed embryos can be enhanced by integrating microfluidic and co-culture techniques. The proposed microfluidic device has ability to automatically trap the individual embryos and coculture it with endometrial cells. The dynamic medium perfusion is also integrated which help to mimics the micro environment like in vivo condition. After culturing the embryo inside the chip for 2-3 days, we can take out the individual mature embryos at a time irrespective of position of the culture chamber for further implantation. The results signify that the development rate in chip is higher than static control method.

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