Abstract
The assessment of interpenetrating (IPN) tensile property, degradation products, tissue adhesive strength, and efficacy of released in situ photopolymerizable drug delivery, was described. The IPNs were photocured in a mold held directly on freshly isolated rat epidermis, dermis, or latissimus dorsi muscle. IPNs exhibited an enhanced elasticity and strength when compared to glutaraldehyde-fixed gelatin hydrogels. The nature of IPN degradation products was independent of the type of gelatin backbone modification. The results show that IPNs have potential as biodegradabe/compatible, tailorable, in situ delivery matrices for therapeutic drugs and cells in wound management and tissue scaffolding.