Abstract
In this work, we propose the employment of chitosan/alginate core-shelled mesoporous nanoparticles to serve as enzyme-controlled cancer drug carriers, as shown in Fig. 1. Enzymes are caged and protected inside the nanoparticles for digesting non-toxic pre-drug into cancer drug and then released into tumor cite by diffusion. According to enhanced permeability and retention effect (EPR effect), nanoparticles tend to accumulate in tumor tissue more than normal tissue.[1] The nanoparticles were fabricated by alginate particles electrospraying in corporate with mesoporous chitosan coating.