Abstract
This paper reports a new on-chip immunological detection system that was detected Hepatitis B surface antigen (HBsAg). The channel fabricated on a chip has unique structures. In order to increase binding efficiency, oligonucleotide (ON) is immobilized on the wall of a shallow part of the channal. And, to enhance detection sensitivity, the depth of a deep part is optimized for the thermal lens measurement. Using this system, we succeeded in detecting 10 pg/mL of HBsAg. Copyright © 2005 by the Transducer Research Foundation, Inc.