Abstract
Mitochondria are pivotal organelles in cells. The unique organelles do not only produce ATP for cells, but also are involved in critical physiological events. Continuous fusion, fission, and transport processes cause mitochondria to form a dynamic network. Previous studies demonstrated that mutations occurred on the proteins promote mitochondria fusion and fission that will lead to inherited neurotrophy and myopathy. Evidences also indicated irregular mitochondrial morphology is correlated to abnormal senescence and neurodegeneration. Furthermore, cancer metastasis and stem cell reprogramming require integral mitochondria dynamics machineries. However, the regulatory pathways that coordinate mitochondria dynamics remain to be explored. Our research aimed to shed light on the regulation of mitochondria dynamics and its correlation to pathogenesis.