Multi-Slice Absolute Cerebral Blood Volume Quantification on Animal Model Using a Hybrid Method of Vascular Space Occupancy and Susceptibility Effect of MION

Cerebral blood volume (CBV) is a valuable physiological parameter for brain research on animal models. In previous study, the vascular space occupancy can achieve absolute quantification of CBV. However, due to using a multi-slice inversion recovery sequence, only one slice can be estimated on the exact blood nulling time. Therefore, we propose a hybrid method by which multi-slice absolute CBV maps are generated by correlating multi-slices relative CBV map by injection of MION to the single slice absolute CBV map by VASO method on the overlapped position. Utilizing the MION's characteristics of high susceptibility effect and long half-life, the feasibility of acquiring high contrast to noise ratio multi-slices absolute CBV maps is studied here.