Abstract
We report multi-step mixing of aqueous solutions of different ion concentration in a T-shaped nanochannel, where symmetry of mixing was broken by the ion hydration effect. When the ion species is K of small hydration radius, the fluidic resistance was increased as pure water probably due to different liquid structure by loosely coupled water molecules by the confinement, while Na and Li of large hydration radius made the fluidic resistance same as the bulk. The present study will contribute to develop nanofluidic systems for integration of chemical processes.