Abstract
We have succeeded in the creation of a new fluid handling system in a microspace using cultured cardiomyocytes as a component of a micropump. In order to communicate the force generated by cardiomyocytes to fluid, a thin diaphragm and a push bar structure made of PDMS were assembled onto a microchannel and cardiomyocytes sheet was attached on them. Estimated flow rate of this micropump was 52nL/min. The applied pressure on the diaphragm generated by cardiomyocytes was 2Pa. This is the first demonstration of micro heart pump using cardiomyocytes sheet only by chemical energy without electrical power supply. ©2005 IEEE.