Abstract
Separation of small chemicals in the extended nanospace channel (10 - 10 nm) was achieved using pressure-driven flow when water was used as a mobile phase. These chemicals were separated well by only passing through the nanochannel by the hydrodynamic flow. Theoretical plate number of peak was higher than that of conventional column and it was expected that it will be over 1,000,000 plates by further optimizations. This possibility showed that the nanochromatography system enable the separation of very small sample (atto L scale) with high efficiency. © 2009 CBMS.