Photothermal optical phase shift microscopy using relay optics for sensitive detection of biomolecules

Shigenori Takeda; Hisashi Shimizu; Kazuma Mawatari; Takehiko Kitamori

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Photothermal optical phase shift microscopy using relay optics for sensitive detection of biomolecules

Shigenori Takeda, Hisashi Shimizu, Kazuma Mawatari and Takehiko Kitamori

21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017, pp.575-576

2020

Appears in keyword about Chemistry

Abstract

Biomolecule

Nano/micro fluidics

Non-label detection

Photothermal spectroscopy

Chemical Engineering (miscellaneous)

Bioengineering

We report non-labeled biomolecules detection in a nanochannel by using UV excitation photothermal optical phase shift (UV-POPS) microscopy. In the present study, we constructed a new optical system using relay optics to achieve single biomolecule detection, and signal-to-background ratio was estimated to be 20 times higher than our previous POPS detector [1].

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Title: Photothermal optical phase shift microscopy using relay optics for sensitive detection of biomolecules
Translated title: Photothermal optical phase shift microscopy using relay optics for sensitive detection of biomolecules
Creators - without role: Shigenori Takeda - The University of Tokyo
Hisashi Shimizu - The University of Tokyo
Kazuma Mawatari - The University of Tokyo
Takehiko Kitamori - The University of Tokyo
Publication Details: 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017, pp.575-576
Identifiers: 9780692941836; 9957770183106774
Academic Unit: Institute of NanoEngineering and Microsystems, College of Engineering, National Tsing Hua University
Language: English
Resource Type: Conference paper

Photothermal optical phase shift microscopy using relay optics for sensitive detection of biomolecules

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