Abstract
This paper describes the development of a non-scanning photothermal imaging method by CCD-based optics. By utilizing visible excitation laser and lamp-based illumination with phase-contrast optics, image-acquiring time was 4 min for 100 μm × 100 μm areas. In the present stage, the system could detect 7.5 × 10 absorbance while normal microscope can visualize 10 absorbance. © 2006 Society for Chemistry and Micro-Nano Systems.