Abstract
Unique liquid properties and its mechanism in nanochannels are now gathering attention, because many researchers are recently utilizing unique characteristics of nanochannel. However, it remains unrevealed due to difficulty of measurement by conventional research tool. Here, we investigated the proton transfer mechanism and the limiting step by isotope effect. As a result, the proton transfer model was supported, and the limiting step was confirmed for the first time, which brings deep insights for nanofluidic design.