Rapid c-reactive protein detection with AlGaN/GaN high electron mobility transistors in an integrated microfluidic system

Cardiovascular diseases are one of the most serious diseases worldwide and cause about 25 million deaths every year. Creactive protein (CRP) in human blood is a well-known biomarker related to the cardiovascular diseases. The concentration of CRP identifies the risk for cardiovascular diseases. To measure the concentration of CRP, the CRP-specific aptamer immobilized AlGaN/GaN high electro mobility transistors (HEMTs) were used to recognize CRP and transfer it into electric signals. The AlGaN/GaN HEMT was further integrated with a multifunctional microfluidic system. The integrated microfluidic system enhanced the detection accuracy with stable detecting environment. It may be promising for on-site monitoring of CRP in the near future.