Abstract
We report a novel sensitive chiral analysis method for microchip-based synthesis or screening system of chiral compounds based on the circular dichroism (CD) thermal lens microscope (TLM) in UV wavelength region for wide range of chiral analysis: UV-CDTLM. The UV (266 nm) excitation laser beam was phase-modulated and used to detect TL effects for the light absorption of left circularly polarized (LCPL) or right circularly polarized (RCPL) beam. We illustrated the principle of UV-CD-TLM, and more than 5 orders higher sensitivity was verified than that in conventional CD spectrometer. © 2006 Society for Chemistry and Micro-Nano Systems.