Abstract
Microfluidic radiosynthesizer and solid phase synthesis methodologies are attractive for rapid production of short-lived radiolabeled probes for positron emitting tomography (PET). Herein, we combined the synergistic properties of a microfluidic synthesizer embedded with a polymer supported precursor to enable diverse production of molecular probes at the point-of-use. In this first proof-of-concept, we have successfully demonstrated the solid phase radiosynthesis on a continuous flow glass microfluidic chip with 75% fluorination efficiency. The use of a simplified linker strategy on a polymerizable substrate within a microfluidic chip could be diversified to synthesize a wide range of PET probes.