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Stack and measurement of zeptomole neurotransmitters released from living single cells on a FASS-nano-fluidic chip with electrochemical detection
Conference paper

Stack and measurement of zeptomole neurotransmitters released from living single cells on a FASS-nano-fluidic chip with electrochemical detection

Ren-Guei Wu, Fan-Gang Tseng and Chung-Shi Yang
Micro Total Analysis Systems - Proceedings of MicroTAS 2006 Conference: 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, pp.954-956
2006

Abstract

Carbon nanotubes (CNTs) Living single cells Nano-fluidic chip Neurotransmitters Zeptomole
This paper demonstrates the detection possibility of zeptomole level neurotransmitters released from two to three living PC-12 cells by employing FASS (the Field-amplified sample stacking) incorporated with a nano Pd-Pt-SWCNT (Pd-Pt nanostructure modified Single-wall carbon nanotube) electrode and integrated on a nano EC-CE (electrochemical capillairy electrophoresis) chip. The detection limit can approach 0.5 nM (∼ 38 zeptomole) dopamine with an S/N ratio > 2 for the releasing from two-three living cells. © 2006 Society for Chemistry and Micro-Nano Systems.

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