Synthesis of boron-10 enriched chitosan coated PVA/alginate nanoparticles (CHI/ALG-PVA-B NPS) by electrospray technique to treat oral squamous cell carcinoma by boron neutron capture therapy (BNCT)

Han-Lin Cho; Venkanagouda S. Goudar; Wei-Jen Chan; Fan-Gang Tseng

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Conference paper

Synthesis of boron-10 enriched chitosan coated PVA/alginate nanoparticles (CHI/ALG-PVA-B NPS) by electrospray technique to treat oral squamous cell carcinoma by boron neutron capture therapy (BNCT)

Han-Lin Cho, Venkanagouda S. Goudar, Wei-Jen Chan and Fan-Gang Tseng

23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019, pp.1590-1591

2019

Appears in keyword about Chemistry

Abstract

BNCT

Boron-10

Electrospray

Nano-drug

Oral squamous cell carcinoma

Bioengineering

Chemical Engineering (miscellaneous)

Boron enriched chitosan coated PVA/Alginate based nano drug were synthesized by electrospray ionization (ESI) process. We confirmed IC-50 value (6.25µg/ml) and cytotoxicity of Chi/Alg-PVA-B NPs drug by WST-1 assay on SAS cell lines by serial dilution of drug from 25ppm to 1.56ppm. In comparison to SAS cell viability of 70% by treated with 25µg/ml boric acid. BNCT treatment in presence of Chi/Alg-PVA-B NPs reduces cell viability to 19% without causing any damage to normal cells.

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Title: Synthesis of boron-10 enriched chitosan coated PVA/alginate nanoparticles (CHI/ALG-PVA-B NPS) by electrospray technique to treat oral squamous cell carcinoma by boron neutron capture therapy (BNCT)
Translated title: Synthesis of boron-10 enriched chitosan coated PVA/alginate nanoparticles (CHI/ALG-PVA-B NPS) by electrospray technique to treat oral squamous cell carcinoma by boron neutron capture therapy (BNCT)
Creators - without role: Han-Lin Cho - Engineering and System Sciences (ESS) , National Tsing Hua University
Venkanagouda S. Goudar - Engineering and System Sciences (ESS) , National Tsing Hua University
Wei-Jen Chan - Engineering and System Sciences (ESS) , National Tsing Hua University
Fan-Gang Tseng - Engineering and System Sciences (ESS) , National Tsing Hua University
Publication Details: 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019, pp.1590-1591
Identifiers: 9781733419000; 9957776195706774
Academic Unit: Department of Engineering and System Science, College of Nuclear Science, National Tsing Hua University
Language: English
Resource Type: Conference paper

Synthesis of boron-10 enriched chitosan coated PVA/alginate nanoparticles (CHI/ALG-PVA-B NPS) by electrospray technique to treat oral squamous cell carcinoma by boron neutron capture therapy (BNCT)

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