Abstract
We demonstrate the synthesis of diverse tracers (sugar, DNA nucleoside, protein labeling compound, and neurotransmitter) using a single electrowetting-on-dielectric (EWOD) chip design with multifunctional electrodes for heating, temperature sensing, and EWOD driving. Furthermore, we present a key advantage of microfluidic chemical synthesis in increasing specific activity (radioactivity per mass of tracer) compared to macroscale synthesis. These are important steps toward more affordable, specific, and universal tracer production for use in positron emission tomography (PET).