Abstract
The amyloid peptide 1-40 forms fibril aggregates having lengths larger than several microns and a diameter around several nanometers. The growth rate and the average length of the fibril can be tuned by adding amphiphilic molecules. In this study, we will show that the addition of dihexanoylphosphatidylcholine (diC 6 PC) can effectively reduce the growth rate of the amyloid fibrils and can be used to tune the average length of the amyloid fibrils. The growth process was studied by using AFM and also dynamic light scattering.