Abstract
This paper reports a detection device which realizes the miniaturization of differential interference contrast thermal lens microscope (DIC-TLM) [1]. The device comprises a Mach-Zehnder interferometer using optical waveguide contacting with a microfluidic channel and detects thermal lens phenomenon based on the principle of wave optics. The device is promising for detection of nonfluorescent molecules in micro/nanofluidic channel comparable or smaller than the wavelength of light.