Abstract
The surface of polyethylene teraphthalate (PET) fabric was modified by Fluoropassiv TM fluoropolymer (FC) and RGD containing peptide. Inflammation against and thrombus accumulation upon modified PET fabric were studied in vivo and ex vivo using three different animal models. Decreased fibrosis and fibroblast proliferation were observed with PET/FC implant compared with the PET and PET/RGD but the difference was relatively small. The PET/FC overall performance proved to be better than PET and PET/RGD in the inflammation models making it more preferable than unmodified PET in cardiovascular device applications.