Ultrasensitive detection of nonlabeled protein using UV photothermal optical phase shift detection

Hisashi Shimizu; Shigenori Takeda; Kazuma Mawatari; Takehiko Kitamori

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Conference paper

Ultrasensitive detection of nonlabeled protein using UV photothermal optical phase shift detection

Hisashi Shimizu, Shigenori Takeda, Kazuma Mawatari and Takehiko Kitamori

22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018, Vol.2, pp.971-972

2018

Appears in keyword about Chemistry

Abstract

Nanofluidics

Optical detection

Photothermal

Protein

Chemistry (all)

Bioengineering

Chemical Engineering (miscellaneous)

Control and Systems Engineering

An ultrasensitive photothermal detection system is developed for nonlabeled proteins. The detection principle is verified, and the mechanism of improvement of signal-to-noise (S/N) ratio is also revealed. As a result, detection of 30 molecules in 1.0 fL detection volume is realized. The detection performance is 20 times improved than our previous detection system.

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Title: Ultrasensitive detection of nonlabeled protein using UV photothermal optical phase shift detection
Translated title: Ultrasensitive detection of nonlabeled protein using UV photothermal optical phase shift detection
Creators - without role: Hisashi Shimizu - International Research Center for Neurointelligence , University of Tokyo
Shigenori Takeda - International Research Center for Neurointelligence , University of Tokyo
Kazuma Mawatari - International Research Center for Neurointelligence , University of Tokyo
Takehiko Kitamori - International Research Center for Neurointelligence , University of Tokyo
Publication Details: 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018, Vol.2, pp.971-972
Identifiers: 9781510897571; 9957767996706774
Academic Unit: Institute of NanoEngineering and Microsystems, College of Engineering, National Tsing Hua University
Language: English
Resource Type: Conference paper

Ultrasensitive detection of nonlabeled protein using UV photothermal optical phase shift detection

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