Abstract
Paper-based digital microfluidic biochip (PB-DMFB) technology provides a promising solution to many biochemical applications. However, PB-DMFB manufacturing process may suffer from potential security threats. For example, both Trojan insertion and man-in-the-middle attack may affect the functionality of PB-DMFBs. To ensure the correct functionality of PB-DMFBs, we propose a watermarking scheme to hides information in the PB-DMFB layout, which allows users to check design integrity and authenticate the source of the PB-DMFB design. As a result, it serves as a first countermeasure against both Trojan insertion and man-in-the-middle attacks for PB-DMFBs.