Yoctomole non-labeled protein detection in extended-nano channel by uv excitation differential interference contrast thermal lens microscopy

Naoya Miyawaki; Hisashi Shimizu; Kazuma Mawatari; Takehiko Kitamori

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Yoctomole non-labeled protein detection in extended-nano channel by uv excitation differential interference contrast thermal lens microscopy

Naoya Miyawaki, Hisashi Shimizu, Kazuma Mawatari and Takehiko Kitamori

MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, pp.1798-1800

2015

Appears in keyword about Chemistry

Abstract

Nanofluidics

Non-label detection

Photothermal spectroscopy

Proteins

Control and Systems Engineering

We report non-labeled protein detection at 100 yoctomole (10 mole) level with an optical path length of 900 nm by improving UV differential interference contrast thermal lens microscopy (UV-DIC-TLM). In the present study, we made UV-DIC-TLM optimized the optical configuration to obtain maximum signal, and realized 15-fold higher sensitivity than previous report [1].

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Title: Yoctomole non-labeled protein detection in extended-nano channel by uv excitation differential interference contrast thermal lens microscopy
Translated title: Yoctomole non-labeled protein detection in extended-nano channel by uv excitation differential interference contrast thermal lens microscopy
Creators - without role: Naoya Miyawaki - Department of Applied Chemistry , School of Engineering , University of Tokyo
Hisashi Shimizu - Department of Applied Chemistry , School of Engineering , University of Tokyo
Kazuma Mawatari - Department of Applied Chemistry , School of Engineering , University of Tokyo
Takehiko Kitamori - Department of Applied Chemistry , School of Engineering , University of Tokyo
Publication Details: MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, pp.1798-1800
Identifiers: 9780979806483; 9957767058706774
Academic Unit: Institute of NanoEngineering and Microsystems, College of Engineering, National Tsing Hua University
Language: English
Resource Type: Conference paper

Yoctomole non-labeled protein detection in extended-nano channel by uv excitation differential interference contrast thermal lens microscopy

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