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Effects of mechanical strain on syndecan-4, focal adhesion complexes, and site-specific FAK phosphorylation
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Effects of mechanical strain on syndecan-4, focal adhesion complexes, and site-specific FAK phosphorylation

C.-M. Cheng, R.L. Steward Jr., D.L. Wang 和 P.R. LeDuc
Proceedings of the ASME Summer Bioengineering Conference, SBC2008, 頁碼.265-266
2009

摘要

Phosphorylation Cellular mechanics Cellular structure External force Focal adhesion kinase Focal adhesions Mechanical strain Mechanical stretch Mechanotransduction Physiological condition Site-specific Adhesion
Cellular mechanics involves the ability of cells to sense and respond to external forces. The type of deformations that cells undergo such as stretching, compression or shearing depends on physiological conditions such as how muscle deforms during movement. Using a custom fabricated stretching device, we focused on investigating how statically applied mechanical stretch affects syndecan-4, focal adhesion complexes and phosphorylated focal adhesion kinase (p-FAK). These results have potential implications in a variety of fields including biophysics, mechanotransduction, and cellular structure. Copyright © 2008 by ASME.

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