摘要
This paper presents a time-domain complementary metal-oxide-semiconductor (CMOS) biosensor monolithically integrated with capillary microfluidics for multiplexed cardiovascular biomarker detection. A CMOS chip with gold interdigitated electrodes combined a correlated double sampling front end and a voltage-to-time converter (VTC) to translate biomarker-induced capacitance changes directly into digital time-domain outputs, thus eliminating external analog-to-digital converters and improving noise robustness over prior voltage-domain designs. A passive plasma-separation microfluidic module delivered plasma from microliter-scale whole blood to an aptamer-functionalized detection chamber aligned to the electrodes. Calibration across clinically relevant ranges for cardiac troponin I, NT-proBNP, C-reactive protein, and fibrinogen yielded linear or logarithmic time-domain responses with coefficients of determination above 0.90. From 20 \mu ~\mathrm{L} of whole blood, the system generated plasma with high purity, demonstrating a compact, low-power platform that might provide CMOS-microfluidic biosensors for practical point-of-care cardiovascular testing.