Abstract
The studies on the asymmetric reactions of aldehydes or ketones catalyzed by Aluminum(III) or Indium(III) complexes with 1,1’-Bi-2-naphthol (BINOL) as chiral ligand are described. This thesis consists of three parts. The first part is concerned with catalytic asymmetric borane reduction of aromatic ketones. Up to 83% ee could be obtained with 10 mol% Al(OiPr)3/BINOL2 complex as catalyst. The second part is about catalytic asymmetric allylation of aldehydes by allyltrimethoxysilane. Moderate yields and ees could be achieved with InBr3/BINOL complex as catalyst. In the third part, In(OTf)3/BINOL was conducted into the asymmetric silane reduction of aromatic ketones as catalyst, and only low ees could be obtained. Modification based on the reaction mechanism has been proposed to improve the enantioselectivity.