Abstract
Early detection of high-grade malignancy, such as pancreatic cancers and glioblastoma multiforme (GBM), significantly increases patients’ survival rate. For this purpose, a new approach, termed “Active-Feedback MR”, was developed. An active-feedback electronic device was homebuilt to implement active-feedback pulse sequences to generate “avalanching spin amplification” effect. This device enhanced the weak magnetic-field perturbations from magnetic nanoparticles in targeted pancreatic cancers or malignant physiological conditions in GBM and improved the contrast of decay constant mapping and MR images.