Human wild type LRRK2 can decrease tauinduced toxicity and increase AKT-FoxO1 signaling activity to promote cell survival.

Dissertation

Lu, Yu-Ning

Doctor of Philosophy (PHD), 國立清華大學, 生物科技研究所

2017

Abstract

帕金森氏症(Parkinson’s disease, PD)

LRRK2 WT

LRRK2 G2019S

Tau 蛋白

過度磷酸化表現

Hypophosphorylate

紡錘狀細胞

Phosphoinositide 3-kinase (PI3K)

Akt

Forkhead box protein O1(FoxO1)

Glycogen synthase kinase 3 beta (GSK3β)

Parkinson’s disease, PD

LRRK2 WT

LRRK2 G2019S

Tau

hyperphosphorylate

hypophosphorylate

Tangle like structure

neurofibrillary tangles

Phosphoinositide 3-kinase (PI3K)

Akt

Forkhead box protein O1(FoxO1)

Glycogen synthase kinase 3 beta (GSK3β)

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Title: Human wild type LRRK2 can decrease tauinduced toxicity and increase AKT-FoxO1 signaling activity to promote cell survival.
Translated title: Human wild type LRRK2 can decrease tauinduced toxicity and increase AKT-FoxO1 signaling activity to promote cell survival.
Creators: Lu, Yu-Ning
Contributors: Chang, Hui-Yun (Advisor)
Awarding Institution: 國立清華大學, 生物科技研究所; Doctor of Philosophy (PHD)
Theses and Dissertations: Doctor of Philosophy (PHD), 國立清華大學, 生物科技研究所
Language: English
Resource Type: Dissertation
Date published: 2018