Abstract
In this thesis, several new nickel and cobalt catalyzed coupling and cyclization of organoboronic acids with carbon carbon □-components are discussed in detail. For convenience and better clarity, the thesis is divided into five chapters. Chapter 1 describes the over view of synthetic and biological applications of organoboronic reagents. Chapters 2 and 3 demonstrate nickel and cobalt catalyzed Mizoroki Heck and Michael type addition of organoboronic acids to α,β-unsaturated alkenes. The possible reaction mechanisms of Mizoroki Heck and Michael type addition reactions are proposed. A cobalt-catalyzed addition reaction of organoboronic acids with alkynes is described in Chapter 4. Isolation of aryl-cobalt intermediate and correlative cobalt complexes strongly support the proposed mechanism. The annulations of ortho-functionalized arylboronic acids with alkynes for the synthesis of isocoumarin derivatives are presented in Chapter 5 along with the biological applications.